Functional Consequences of Toll-like Receptor 4 Polymorphisms
نویسندگان
چکیده
منابع مشابه
Functional consequences of toll-like receptor 4 polymorphisms.
Toll-like receptor 4 (TLR4) is an important pathogen recognition receptor that recognizes mainly lipopolysaccharide (LPS) of Gram-negative bacteria, but also structures from fungal and mycobacterial pathogens, as well as endogenous ligands. Two nonsynonymous polymorphisms of TLR4, Asp299Gly and Thr399Ile, have been suggested to alter the function of the receptor. Some, but not all, studies have...
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Objective(s): This study was aimed to evaluate whether single nucleotide polymorphisms (SNPs) of TLR4 and common living habits of prostate hyperplasia (BPH) patients would affect the subjects’ risk and prognosis.Materials and Methods: We totally recruited 501 BPH patients and 964 healthy controls. The patients’ international prostate symptom score (IPSS) and quality of life assessment (QoL) wer...
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Profound thrombocytopenia occurs in humans with sepsis and in mice administered lipopolysaccharide (LPS). Growing evidence indicates that platelets may contribute to these abnormalities, but whether that is a direct result of LPS activation of platelets or an indirect result of other inflammatory mechanisms remains unclear. Here we demonstrate that although platelets do not increase P-selectin ...
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BACKGROUND Lipopolysaccharide (LPS or endotoxin) exposure resulting from microbial invasion of the endometrium disturbs the Th1/Th2 balance at the feto-maternal interface and has been linked to the risk of idiopathic miscarriage in a range of human and animal studies. Toll-like receptor 4 (TLR4) mediates LPS signalling, and the human TLR4 gene harbours two single-nucleotide polymorphisms (SNPs)...
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Is there an association between impaired pulmonary function and mortality in never smokers? I read with great interest the article by Mannino et al 1 on the association between impaired pulmonary function and mortality, and wish to comment on two statements in the paper. Firstly, the authors report that ''an interesting finding in (their) analysis was that, in never smokers, moderate or severe ...
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ژورنال
عنوان ژورنال: Molecular Medicine
سال: 2008
ISSN: 1076-1551,1528-3658
DOI: 10.2119/2007-00135.ferwerda